Vaccine toxicity studies
Citoxlab – Your one-stop CRO for vaccine development
The impact of vaccination on infectious diseases and public health in countries around the world has been enormous. Many previously dreaded infectious diseases are now largely controlled by effective vaccination programmes and progress to develop further vaccines is being made.
Advances in our understanding of basic immunology have given greater insight into the working of vaccines. Building on this understanding, we are living in a period of intense research and creativity in vaccine-based therapies. A new generation of “therapeutic” vaccines seems presently to be poised to provide novel therapeutic approaches to non infectious chronic diseases such as cancer, asthma, diabetes, hypertension and others.
Our teams have experience with toxicology and safety evaluation of a wide range of vaccine types, including inactivated bacterial and viral vaccines, live attenuated vaccine strains, recombinant and engineered proteins, polysaccharide and conjugated vaccines, DNA vaccines and therapeutic vaccines.
Your products are unique, so the objective of our teams is providing you with the ideal package for exploring the potential toxicity of your drug candidates.
Toxicity investigations for new vaccine preclinical safety evaluation packages include :
- Single dose
- Local tolerance
- Immune response
- Repeat dose
- Reproductive toxicology
- Safety pharmacology