In vitro toxicology for chemicals
Citoxlab – Your one-stop CRO for chemicals, agrochemicals and biocides
In vitro toxicology is a key aspect of REACH and chemical notifications. Current EU regulations on agrochemicals also contain a specific requirement to use in vitro methods. Our experts have extensive experience, including test development, managing international validations and writing OECD guidelines. Citoxlab routinely performs GLP tests to meet international requirements for CLP/GHS and other regulatory labeling purposes, and screening for potentially severe effects before live animal studies are permitted.
In vitro methods are particularly suited to candidate selection screening and for understanding issues with a mechanistic approach, and they can increasingly provide stand-alone data for specific end‑points without a need for in vivo confirmatory studies.
- Eye irritation
- Isolated chicken eye test (OECD 438); can be used as a stand-alone study to classify non-irritants (with 82% accuracy) and irritants
- BCOP (OECD 437)
- Skin corrosion
- EPISKIN (OECD 431) provides subcategory classification as well as a positive/negative result
- Skin irritation
- EPISKIN (OECD 430) provides regulatory classification for irritation
- Skin sensitization (methods under discussion by the OECD before issue of formal guidelines)