Acute toxicology and local tolerance for chemicals

Citoxlab – Your one-stop CRO for chemicals, agrochemicals and biocides

CLP/GHS regulations concerning product labelling and transport of chemicals, biocides and agrochemicals generally require acute toxicity evaluations by inhalation, oral, dermal and ocular routes of exposure, as well as in vitro studies. These are frequently performed as a “six pack” to provide the full registration data for acute effects.

Expert preparation of your product in liquid or atmosphere formulations suitable for accurately dosed administration, and high quality animal welfare care are hallmarks of our in vivo studies.

Substances can be screened using in vitro tests; some regulatory authorities accept in vitro results alone for classification purposes.

Our study directors aim to provide you with professional services, performing studies and producing clearly explained scientific reports that meet regulatory requirements in line with your product development objectives.

Acute Testing

  • Oral toxicity (OECD 423, 425 and 420)
  • Dermal toxicity (OECD 402)
  • Inhalation acute toxicity (OECD 403 and 436)
  • Skin sensitization
    • LLNA (OECD 429)
    • Buehler or GMPT (OECD 406)
    • In vitro methods
  • Eye irritation
    • In vitro (OECD 438 and 437)
    • In vivo (OECD 405)
  • Skin corrosion / irritation
    • In vitro (OECD 431 and 439)
    • In vivo (OECD 406)