In Vitro Cardiovascular and Central Nervous System electrophysiology services
Citoxlab – Your one-stop CRO for in vitro electrophysiology
Many promising drugs have either been withdrawn from the market or classified into ‘restricted use’ categories due to unforeseen adverse effects on either the heart or central nervous system. In light of this, Citoxlab is now happy to offer a variety of cardiovascular (CVS) and central nervous system (CNS) in vitro electrophysiology services aimed at identifying these potential CVS and CNS liabilities early in the drug development process.
In Vitro Cardiovascular System electrophysiology services
One of the most important CVS liabilities in safety pharmacology is the life-threatening condition known as Torsades de pointes (TdP). This condition is principally mediated by alterations in the activity of the hERG (Kv11.1) channel. However, other important cardiac ion channels (Cav1.2, Nav1.5, Kv4.3, Kir2.1 and Kv7.1) involved in the cardiac action potential have also been implicated. Accordingly, Citoxlab has developed a GLP-compliant, in vitro electrophysiological service which offers clients a robust ion channel platform from which to characterize the mechanism of action and safety of a lead compound. This in vitro cardiac profile screen provides a comprehensive safety analysis including inhibition tests and IC50 metrics.
In Vitro Central Nervous System electrophysiology services
Adverse CNS effects have also played an important role in the failure of many drug candidates within preclinical safety assessments. To help address these potential liabilities, Citoxlab offers a range of in vitro electrophysiological assays to evaluate seizure risk, drug induced cognitive dysfunction risk, dorsal root ganglia responses or nerve conduction effects. These assays have been developed, and are offered, in several preclinical animal models such as the mouse, rat, minipig, dog and non-human primate to allow species comparison.
Our team of pharmacologists dedicated to drug safety testing is available to help progress your program.