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immunotoxicologyImmunotoxicology

Citoxlab – Your one-stop CRO for immunotoxicity testing

Over the years we have partnered with many companies to investigate immunotoxicology of candidate drugs.

In addition to advice on study design, and discussions to find the most relevant endpoints for your projects, we can offer you access to the latest technologies along with our experience in a wide range of in vitro and in vivo immunotoxicology assays. The list of biomarkers is continually expanding as scientific development progresses and new technologies are validated, so do not hesitate to get in touch with us and keep up with the most recent advances.

Our scientists will help you find solutions to all aspects of immunotoxicology, immunosuppression, immunomodulation, immunogenicity, hypersensitivity :

  • Standard clinical and histopathology methods
  • Immune function studies
    • T-dependent antibody response (TDAR) assay
    • Immunophenotyping in blood (flow cytometry) and tissues (immunohistochemistry)
    • Natural Killer cell activity measured by flow cytometry
    • Delayed-type hypersensitivity
    • Neutrophil function (Phagotest°, Phagoburst)
    • Lymphocyte proliferation assay
    • Cytokine quantification by ELISA
    • Cell mediated responses by ELISPOT
  • Hypersensitivity/Immunogenicity
    • Complement protein titration
    • Murine local lymph node assay
    • Guinea pig maximization test and Buehler test
    • Histamine release assay
    • IgE titration
    • Antidrug antibody (ADA) assays