In vitro toxicology
Citoxlab – Helping to put the right drug candidate forward
In vitro toxicology is a key aspect of the discovery and predictive phase of product development. Current EU regulations specifically require the use of in vitro methods for agrochemicals and cosmetics, and in vitro screening can identify potentially severe effects before beginning in vivo studies.
We have extensive experience in test development, managing international validations, writing OECD guidelines and performing in vitro toxicology studies to meet international requirements for regulatory labeling purposes (including CLP/GHS).
In vitro methods are well suited to candidate selection screening and for understanding issues with a mechanistic approach. They can increasingly provide stand-alone data for specific endpoints without in vivo confirmatory studies.
Some discovery and predictive phase fields where an in vitro approach for ethical reasons is particularly recommended are:
- Eye irritation
- Skin corrosion
- Skin irritation
- Skin sensitization
After the discovery and predictive assessment stages, a whole range of in vitro services is available for further development phases.