Services

Core battery toxicology:

 

  • Genotoxicity: mini-Ames, BlueScreen™, in vitro micronucleus
  • General  toxicology in all Rodent and Non-Rodent Species (including Minipig & NHPs)
  • In vivo lead optimization predictive toxicology
  • Toxicogenomics: Affymetrix
  • Safety  pharmacology including telemetry studies
  • Bioanalysis: LC-MS/MS, GC-MS/MS,  LC-ICP/MS
  • Formulation Analysis (HPLC)
  • Radiolabelled DMPK
  • Efficacy models
  • Reproductive toxicology, DART (including minipigs)
  • Carcinogenicity studies:  also in rasH2 and p53+/- mice
  • Physical chemistry

Leading edge expertise:

 

  • Juvenile studies (including minipigs)
  • Early toxicology: LeadScreen™ 14 days multi-endpoint in vivo toxicology screening
  • Non-human primates and transgenic rodents, including disease models
  • Biomarkers & Immunology: 10-color flow cytometer and Luminex
  • Tissue Cross Reactivity: human tissue bank
  • Bioanalysis & Immunogenicity by ELISA: custom designed
  • Biodistribution via qPCR
  • Image  analysis
  • Infusion
  • Inhalation
  • Dermal and Wound Healing
  • QSAR

Other key expertise:

 

  • Immunotoxicology
  • Ecotoxicology
  • Agrochemical testing
  • REACH certification and GLP services
  • devTOX™ & cardioTOX™
  • Radiation Safety (ARS)