Clinical & Anatomical Pathology

CiToxLAB histology laboratories can offer all routine procedures, along with special techniques such as immune-histochemical and fluorescence staining on paraffin, frozen or plastic blocks.

 

State-of-the-art equipment including GLP-validated software (Provantis, Pathdata, Bone, Cell D) are dedicated to histology operations.

 

Our team of certified and experienced veterinarians, pathologists and technical staff has a wealth of expertise in evaluating the safety of pharmaceutical, veterinary pharmaceutical, biotechnological, medical device, chemical, agrochemical, food and consumer products, in rodents and non-rodents.

 

 

Proficient routine expertise

 

Necropsy

 

  • Skilled prosectors
  • Whole and upper body perfusion in rodent and non-rodent species
  • Special collection procedures for immunohistochemistry, genomics, neurotoxicology and electron microscopy
  • Quick and careful tissue collection for RNA or DNA extraction
  • Bone collection for histomorphometry
  • Online data acquisition (organ weights and gross observations)

Histology

 

  • Highly experienced staff
  • Organ trimming according to RITA-like instructions for rodent species
  • Organ trimming according to RITA-like instructions for non-rodent species
  • Consistent presentation of tissues on slides
  • Paraffin, frozen and methacrylate embedding
  • Standardized and special staining procedures
  • Paraffin, plastic and cryosectioning
  • Immunohistochemical and fluorescence staining of paraffin embedded or frozen tissues

Pathology

 

  • Experienced Board Certified (ACVP and ECVP) Veterinary Pathologists
  • Evaluation of a wide range of studies in rodents and non-rodents, from acute to chronic oral injection/infusion, dermal, inhalation, irradiation and local (incl. wound healing) toxicity, developmental and reproductive, intravesical and carcinogenicity studies
  • Glossary defined according to the international recommendations for terminology
  • Historical control data from rodents and non-rodents for use with toxicology and carcinogenicity studies
  • Routine internal peer-review
  • lmmunotoxicology
  • Testicular and ovarian staging
  • Histomorphology to quantify tissue changes
  • Online data acquisition
  • Digital imaging, high resolution photographs, telepathology
  • Board Certified Pathologists may read or review your slides at your facility